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CSF-derived myeloid cells express gene signatures of brain resident microglia and border macrophages

Figure 3

• A ) Heatmap expression of the microglia signature gene set defined by Gosselin et.al., 2017 in CSF and peripheral blood derived myeloid and lymphoid cells.
• B ) Heatmap expression of brain border associate macrophage markers in CSF and peripheral blood derived myeloid and lymphoid cells.
• C ) Heatmap expression of genes enriched in the CSF compartment.
• D ) Unbiased identification of gene modules enriched based on compartment (CSF vs PBMC) or based on cell type (lymphoid vs myeloid).Color represents correlation coefficient and value inside each square is the p-value for significant association.
• E ) Genes in the brown module are enriched in CSF myeloid cells, while genes in the black module are enriched in the CSF compartment across both myeloid and lymphoid cells.
• F ) Gene set enrichment analysis of the black and brown module genes using biological processes and molecular pathways.
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